The Project Rx Blog
Treatment Insights
In-depth guides to our treatments — how they work, what to expect, and who they're for. Written for patients, reviewed by physicians.
Enclomiphene for Women: The SERM That Restores Hormone Balance Without Suppressing Ovulation
Unlike traditional hormonal therapies, enclomiphene stimulates the body's own estrogen production by acting on the hypothalamus and pituitary. Here's why this selective estrogen receptor modulator is gaining attention in women's hormone care.
Estradiol Gel for Menopause: The Transdermal HRT That Bypasses the Liver
Estradiol gel delivers bioidentical 17β-estradiol through the skin, bypassing first-pass liver metabolism for more stable blood levels and a more favorable cardiovascular risk profile than oral estrogen.
The Estradiol Patch: Steady, Set-and-Forget Hormone Therapy for Perimenopause and Menopause
The transdermal estradiol patch delivers a continuous, controlled dose of bioidentical estrogen twice weekly — without daily application, peak-and-trough fluctuations, or the liver metabolism concerns of oral pills.
Oral Estradiol Tablets: Flexible, Accessible, and Physician-Guided HRT
Oral estradiol tablets are one of the most commonly prescribed forms of bioidentical hormone replacement therapy. Here's how they work, what differentiates them from transdermal options, and what women should know before starting.
Progesterone and Perimenopause: The Hormone Most Women Are Missing — And Why It Matters
Natural micronized progesterone is the missing piece in many women's hormone protocols. Here's the clinical case for progesterone in perimenopause and menopause, how it differs from synthetic progestins, and what to expect.
Finasteride for Hair Loss: The Clinical Science of Blocking DHT and Regrowing Hair
Finasteride is the most evidence-supported oral treatment for androgenetic alopecia — pattern hair loss — with clinical trials showing 90% of men halt progression and up to 65% experience measurable regrowth at two years.
The Triple-Action Topical: How Compounded Minoxidil + Finasteride + Retinoic Acid Outperforms Single-Agent Hair Loss Treatments
Combining minoxidil, finasteride, and retinoic acid in a single compounded topical formula addresses hair loss through three distinct mechanisms simultaneously — and clinical evidence supports the superiority of combination therapy.
Oral Minoxidil for Hair Loss: Why Physicians Are Prescribing the Pill Over the Topical
Low-dose oral minoxidil is gaining rapid momentum in dermatology as a more effective and more convenient alternative to topical solutions — with early clinical data showing superior hair density results at a fraction of the dose.
Injectable B-12: Why the Shot Delivers What Oral Supplements Simply Cannot
Oral B-12 supplements depend on a functional intrinsic factor pathway to be absorbed — a system that fails in a significant percentage of adults. Injectable methylcobalamin bypasses this entirely, delivering therapeutic levels directly to the bloodstream.
Injectable Glutathione: The Master Antioxidant Protocol for Cellular Defense and Skin Clarity
Glutathione is the body's most abundant intracellular antioxidant — but oral supplements are poorly absorbed. Injectable glutathione bypasses the digestive system entirely, delivering meaningful levels for cellular protection, liver support, and skin clarity.
Injectable NAD+: The Longevity Coenzyme That Declines With Age — and How to Restore It
NAD+ (nicotinamide adenine dinucleotide) is involved in over 500 enzyme reactions and declines by approximately 50% between ages 40 and 60. Injectable NAD+ restores cellular energy capacity and activates longevity pathways that supplementation alone cannot reach.
NAD+ Cream: Topical Cellular Repair for Skin Aging, DNA Maintenance, and Recovery
NAD+ cream delivers nicotinamide adenine dinucleotide directly to skin cells through topical application — supporting local DNA repair, collagen synthesis, barrier function, and visible anti-aging without systemic administration.
NAD+ Nasal Spray: The Fastest Route to Cognitive Performance and Energy Restoration
Intranasal NAD+ delivery reaches systemic circulation faster than any non-IV route — and may access CNS pathways more directly than intramuscular injection. Here's the science behind NAD+ nasal spray and who benefits most.
Sermorelin vs. Synthetic HGH: Why This Peptide Is Winning the Growth Hormone Debate
Sermorelin stimulates your pituitary gland to produce its own growth hormone naturally — preserving the body's feedback mechanisms that synthetic HGH bypasses entirely. Here's what the science shows and why the distinction matters.
Lipo-B Injections: The Lipotropic MIC + B12 Formula for Fat Metabolism and Energy
Lipo-B combines methionine, inositol, choline, and B12 — four nutrients essential for hepatic fat processing and energy production. Here's the science behind lipotropic therapy and how it fits into a physician-supervised weight management protocol.
Lipo-C Injections: The Advanced Lipotropic Formula With L-Carnitine for Enhanced Fat Burning
Lipo-C builds on the Lipo-B formula by adding L-carnitine — the critical transporter that shuttles fatty acids into mitochondria for oxidation. Here's why this upgrade matters for patients in physician-supervised weight management programs.
Compounded Injectable Semaglutide: Everything You Need to Know Before Starting
Compounded injectable semaglutide offers physician-supervised access to GLP-1 receptor agonist therapy. Here's the complete guide: how it works, what the clinical data shows, how it differs from brand-name options, and what to expect.
Compounded Injectable Tirzepatide: The Dual GIP/GLP-1 Protocol and What the Data Shows
Tirzepatide is the first dual GIP/GLP-1 receptor agonist — and SURMOUNT clinical trials have produced the most impressive weight loss outcomes ever recorded for a pharmacological intervention. Here's the full clinical picture.
Liraglutide: The Once-Daily GLP-1 That Pioneered Physician-Supervised Weight Loss
Before semaglutide dominated headlines, liraglutide was the GLP-1 medication that demonstrated for the first time that appetite-regulating hormones could produce clinically meaningful weight loss. Here's the full clinical story.
Microdosing Semaglutide: A Gentler Entry Into GLP-1 Therapy With Fewer Side Effects
Microdose semaglutide uses sub-therapeutic starting doses combined with B12 to introduce GLP-1 therapy gradually — minimizing GI side effects while allowing the patient's system to adapt before titrating toward effective doses.
Microdose Tirzepatide: The Low-Dose Protocol That Reduces Side Effects Without Sacrificing Results
Microdose tirzepatide allows patients to access dual GIP/GLP-1 therapy with a gradual titration that minimizes the GI side effects driving early discontinuation — while still delivering clinically meaningful weight management support.
Sublingual Semaglutide: The Needle-Free GLP-1 Option for Patients Who Can't Tolerate Injections
Sublingual semaglutide delivers GLP-1 receptor agonist therapy through oral mucosal absorption — bypassing the needle entirely while providing clinically meaningful bioavailability for appetite regulation and weight management.
All content is for educational purposes only and does not constitute medical advice. Treatment decisions are made by licensed healthcare providers based on individual medical evaluation. Not everyone qualifies for every treatment. Consult with a licensed provider before starting any treatment program.